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Hello Reader,
My career journey is rooted in the exhilarating world of deep-tech—think semiconductors, algorithms, and those fundamental breakthroughs that literally built Silicon Valley! For years, deep-tech was venture capital, defining the industry and my path alongside it.
While the startup scene has since exploded into everything from consumer apps to finance, deep-tech is back in the spotlight, driving the next wave of disruptive ideas.
Want the inside scoop? I'm excited to feature Debjit Mukerji, a brilliant technologist and VC, on the latest podcast episode. Tune in to hear his deep dive on cutting-edge AI implementation and the next big investment areas at NGP Capital!
Upcoming Events:
- April 16 in Los Altos: Engineering in the age of AI by Funda
- May 7 in in Fontainebleau, France: Lecture on “Startups in the age of AI” to MBA students at INSEAD
– Gopi Rangan, Host of the The Sure Shot Entrepreneur podcast
Startup Corner: PAXAFE
“It Was Never the App,” is the core argument in Ilya Preston’s recent blog post. And the argument is simple but powerful: most startups, and even entire industries, misdiagnose the real problem. In cold chain logistics, companies poured billions into visibility tools (apps, dashboards, and sensors) believing more data would solve product loss. But the issue wasn’t lack of visibility; it was the absence of decision-making systems and orchestration. Data without context, workflows, and actionability only creates noise, not outcomes. Ilya highlights that real value comes from connecting planning, execution, and feedback loops into a continuous system that enables faster, smarter decisions—not just better monitoring. The takeaway for founders is clear: don’t build surface-level solutions to poorly defined problems. Instead, go deeper, understand the full system, identify where decisions break down, and design products that drive action, not just insight.
Ilya Preston is the founder and CEO of PAXAFE, a logistics orchestration and AI‑powered decision intelligence platform for cold chain and high‑value supply chains. Its software goes beyond basic visibility by contextualizing real‑time IoT and shipment data, quantifying risk, and offering actionable recommendations that help companies reduce product loss, optimize operations, and make smarter decisions proactively—especially for temperature‑sensitive goods like pharmaceuticals and perishables.
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New Podcast: Deep tech’s moment has arrived
In Episode 186, my guest is Debjit Mukerji from NGP Capital. Debjit shares why now is the defining moment for Deep Tech—and what separates the founders who break through.
Debjit explains that deep tech is no longer just about breakthrough ideas in labs. A powerful convergence is happening: AI advancements, hardware acceleration, and real-world demand—especially driven by labor shortages and industrial transformation—are pulling these technologies into mainstream adoption faster than ever before. He also reveals how he evaluates founders. It’s not pedigree that matters most, but intensity, curiosity, and resilience. The best founders don’t just build great technology; they show why this is the exact moment their company must exist, and why they are uniquely built to do it.
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Connected Insights: Conviction in the absence of traditional metrics
We had an interesting conversation with Karthee Madasamy in episode #107, and a key theme unique to deeptech emerged: the importance of conviction in the absence of traditional metrics. In deep tech, progress is rarely measured by revenue or customer growth early on, but by technical milestones that signal feasibility and future impact. This requires investors and founders to think differently about what “traction” really means. Karthee emphasizes that the strongest founders don’t rely on projections; instead, they clearly articulate the problem, explain why it matters, and demonstrate why their solution is uniquely positioned for where the market is heading. This aligns with a broader pattern across top operators and investors: early-stage success is less about proving the present and more about convincingly mapping the future. Ultimately, whether in deep tech or other domains, building belief, grounded in insight, is what unlocks early support.
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Community Involvement: MedShare
Beyond venture capital, Debjit Mukerji is deeply committed to giving back through his support of MedShare, a nonprofit tackling a critical yet often overlooked issue: medical waste. In the U.S., vast quantities of usable, sterile medical supplies are discarded due to strict regulations. MedShare steps in to recover these items—ranging from basic supplies like gauze and bandages to mobility equipment—and redistributes them to underserved communities both domestically and across more than 100 countries.
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